Healthy CoQ10 Max-Sorb™ is an all-natural, proprietary, patent-pending, crystal-free, solvent-free, lipid-stabilized CoQ10 softgel formulation shown in recent clinical trials to be over eight times more absorbable than powdered forms of CoQ10 and more than twice as bioavailable as other oil-based or so-called “Nano”- dispersed formulas. CoQ10 Max-Sorb's proprietary monoglyceride carrier is a patent-pending formulation unmatched for optimal utilization in the support of cardiovascular, CNS, immune and energy-based health needs.

Healthy CoQ10 Max-Sorb has the following qualities:

• Maximum Absorption – over 800% better absorbed than CoQ10powder
• Maximum Bioavailability – over 440% more bioavailable than CoQ10 powder.
• Crystal-Free with no solvents used.
• Patent-Pending lipid tri-blend formulation dissolves CoQ10, prevents re-crystallization, and enhances absorption.
• All natural – no chemical additives.
• IRB Registered Double-Blind Human Clinical Study - 20 human subjects showing highest peak absorption and steady state bioavailability for Healthy CoQ10 Max-Sorb™

A Brief Background on CoQ10

Coenzyme Q10 caught the attention of scientists and medical researchers as far back as 1957. Originally discovered by Frederick Crane, Ph.D., at the University of Wisconsin, future research by his colleagues determined that CoQ10 was present in every cell in the body (in the cell organelle membranes and mitochondria) — and is highly critical for cellular energy, longevity, and the health of such organs as the heart, kidneys, and liver. In fact, it’s responsible for 95% of all the energy produced in the mitochondria and used by the body.

However, the body’s production of CoQ10 diminishes with age, drug therapy, and diseases. Young and healthy individuals produce about 3-5 mg of CoQ10 per day. But after age 30, the production levels decline, thus the need for supplementation. Additionally, certain disease states are improved by CoQ10 supplementation.

Forms of CoQ10 in the Body

CoQ10 is found as two major forms in the body, oxidized (ubiquinone) and reduced (ubiquinol), with the reduced form being predominant (over 90%). CoQ10 acts as an antioxidant in its reduced form, but its benefits go far beyond cleaning up free radicals in the body. Studies show that the oxidized form is an essential element in energy production… electron transfer… ATP production… and control of oxidative reactions. It also plays a key role in the treatment of cardiovascular illnesses, including congestive heart failure and angina. Recent studies show that it’s also very effective in the treatment of Parkinson’s disease and cancer.

Manufacturing CoQ10

Many technical challenges have had to be overcome in manufacturing CoQ10 in a form that can be readily absorbed and assimilated by the human body.

First of all, the CoQ10 molecule is rather large. And until recently, it was only manufactured in the oxidized, crystalline (powder) form. Unfortunately, crystalline CoQ10 is nearly impossible for the body to absorb simply because the crystalline form has an extremely high melting point — 118 degrees Fahrenheit — 20 degrees above body temperature! That’s the reason why the powder CoQ10 formulas exhibited such low absorption rates at around 1%.

Therefore, scientists have worked diligently for the past two decades to develop CoQ10 in a form that could be more easily absorbed and put to use in the body. The challenge was to improve on the low absorption rate of the powder (usually tablet or capsule) form.

The first innovation came with “softgel” formulas, which are oil soluble. This improved absorption of the CoQ10 to around 2.5%. Then came two patented softgel formulas with improved absorption of around 3-4%.

Later attempts included a so-called “reduced” CoQ10, which employed better marketing than science (even the “reduced” CoQ10 softgels only had absorption of less than 3%) — as well as “nano” CoQ10, a much smaller carrier system of CoQ10 whose absorption is still questionable.

But today, we at Supplement Spot are proud to announce the development of a true breakthrough in CoQ10 absorption and bioavailability.

Introducing Healthy CoQ10 Max-Sorb™— The “Clear” Winner

The problem with all the other “softgel” attempts at delivering CoQ10 to the absorption cells is that, after the manufacturing process, the CoQ10 re-crystallizes inside the softgel — and often creates larger crystals than the finely-milled starting material.

To get around that, some manufacturers resorted to using solvents (such as D-Limonene and Vitamin E) in their formulas to solubilize the CoQ10 crystals. But even these solvents present a problem inasmuch as they did not facilitate the absorption and may even interfere with the CoQ10 absorption process.

Here at Healthy Aging Nutraceuticals, however, we discovered a proprietary process to keep the CoQ10 in its purest crystal-free form without resorting to solvents. Utilizing a proprietary, lipid tri-blend formulation enables our product to be 100% crystal-free (amorphous) — and therefore increases the absorption and bioavailability dramatically.

In fact, double-blind placebo-controlled human clinical studies have shown the following evidence that our new CoQ10 formula — Healthy CoQ10 Max-Sorb™— is by far the clear winner in today’s quest to achieve a superior CoQ10 product.

How Does Healthy CoQ10 Max-Sorb Work?

Healthy CoQ10 Max-Sorb™’s high absorption and bioavailability came as no accident. There are a number of formulation techniques that were utilized:

1. Patent-Pending, Proprietary Lipid Tri-Blend
   -- A number of different lipids were tested to solubilize and enhance the absorption of CoQ10. After testing dozens of oils, our researchers discovered that a tri-blend of Conjugated Linoleic Acid, Flaxseed Oil, and Monoglycerides yielded the best absorption results. However, you can’t simply mix these three oils with CoQ10 and pump it into a softgel. A proprietary treatment of this lipid tri-blend is necessary to keep the CoQ10 solubilized and enhance its absorption into the body. This is the key in making Healthy CoQ10 Max-Sorb a unique, successful formulation.
2. No Solvents. All Natural.
   --As mentioned earlier, other manufacturers used solvents, such as D-Limonene, to keep the CoQ10 solubilized in the formula. The only problem with this is that these solvents also inhibited the absorption of CoQ10 by the body.
3. Larger Volume
   --Taking a page out of pharmacology, the absorption of an active ingredient can be improved by increasing the surface area of the active dose. For example, a 50 mg Healthy CoQ10 Max-Sorb™ softgel comes in a size 14 oblong softgel. Other 50 mg CoQ10 softgels are usually found in a smaller 7.5 oval size.
   
   The larger softgel volume allows the CoQ10 in Healthy CoQ10 Max-Sorb™ to be solubilized in a larger lipid solution, so when it hits the intestine (where CoQ10 is absorbed), a larger surface area is covered — allowing for increased absorption.
   
   In addition, the highly absorbable monoglycerides, part of the lipid tri-blend, enhances the absorption of CoQ10 into the body.

The Study

In this study, Healthy CoQ10 Max-Sorb™ was compared to a standard dry CoQ10 powder. Normal healthy subjects taking no CoQ10 supplementation CoQ10 medications that interfere with CoQ10 synthesis (such as statins, anti-depressants, hypoglycemics, antibiotics, chemotherapy, etc.) were chosen for this experiment. Blood samples were taken for plasma CoQ10 levels. Each subject was given his or her randomly assigned product and took same in the presence of the medical director. Additional blood samples were taken at 2, 4, 6, 8, 10, 12, 24, and 36 hours. During this time period, the subjects took no further product.

The results of the 36-hour absorption study showed that Healthy CoQ10 Max-Sorb™ had a total absorption of 7.89% (% of dose absorbed at Cmax) compared to 0.87% for standard dry CoQ10 powder, which makes Healthy CoQ10 Max-Sorb™ over 800% more absorbed than CoQ10 powder. The estimated total absorption for Healthy CoQ10 Max-Sorb™ was 11.56% compared to only 3.2% for the standard dry powder.

After the 36-hour peak absorption study, each subject was given a one month supply of their assigned product and instructed to take a single dose each morning with a breakfast containing some fat. They were instructed to follow their normal diet and daily activities, and returned to the testing facility on days 7, 14, 21, and 28 in a rested and fasted condition to test their basal CoQ10 levels after taking daily doses.

The results of the 28-day steady state study showed that at the end of 28 days, there were 8.99 mg of Healthy CoQ10 Max-Sorb™ available for use by the cells, compared to 1.62 mg of dry powder CoQ10. This clearly makes Healthy CoQ10 Max-Sorb over 440% more bioavailable than powder CoQ10 products. Similarly, the area under the bioavailability curve (AUC) showed that the 28 day AUC for Healthy CoQ10 Max-Sorb™ was 53.5 ug/ml.day compared to only 9.9 ug/ml.day for the standard dry powder.

Clearly, Healthy CoQ10 Max-Sorb™ produces over FOUR TIMES greater bioavailability than the old powder form—as well as EIGHT TIMES greater absorption.

When it comes to CoQ10, absorption is the key. Bioavailability is a measure of accumulated CoQ10 in blood that is available to body cells, and absorption must occur before CoQ10 can be made available to the body.

The main physical feature of the Healthy CoQ10 Max-Sorb™ formula is that the CoQ10 is solubilized and stabilized in a lipid tri-blend. This means the CoQ10 is stable and will not re-crystallize — and the softgel remains perfectly clear throughout the shelf-life of the product. The ultimate result is improved absorption and bioavailability, and improved overall efficacy of the CoQ10 supplement.

Plus, Healthy CoQ10 Max-Sorb™ has been shown to be insensitive to light. One of the “marketing myths” being promoted is that CoQ10 is light sensitive, and therefore must be put into a colored, opaque shell. The truth is CoQ10 is not light sensitive. To prove this, we had Healthy CoQ10 Max-Sorb™ tested for photo-sensitivity (there are only a couple of FDA drug labs approved to do this test), and it passed with flying colors with only 1% degradation, which is better than most drugs.

The Healthy CoQ10 Max-Sorb™ difference is clear. And when consumers see this—and then discover that with Healthy CoQ10 Max-Sorb™ they’re getting over four times greater bioavailability… and eight times greater absorption… they’ll quickly abandon their former CoQ10 brands in favor of anyone offering Healthy CoQ10 Max-Sorb™.

Coenzyme Q10 is one of those few nutrients that benefits nearly everyone.

Other ingredients: Conjugated Linoleic Acid, Flaxseed Oil, Monoglycerides, Glycerin, Water

** Daily Value has not been established.

Dosage
Suggested Use: As a dietary supplement, take 1 capsule once or twice a day or as directed by your Health Care Practitioner.

Cautions
As always, consult your physician before taking supplements, especially if you have a medical or psychiatric condition, or are pregnant or lactating.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.